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This does not mean every patient with autism has a creatine deficiency, but it provides a plausible biochemical connection between methylation demand and poor energy resilience

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The manipulated eggs were culture to the two-cell stage and transferred into oviducts of pseudopregnant foster females (ICR strain)

Figure 1 Wnt signaling is known to regulate a wide range of developmental processes such as body axis and segment polarity, mesoderm and endoderm differentiation, hair follicle and nephron development, and epithelial-mesenchymal transition (Logan and Nusse, 2004)